Lack of connexin 40 causes displacement of renin-producing cells from afferent arterioles to the extraglomerular mesangium

DOI to cite this document:: 10.5283/epub.2035

Kurtz, Lisa ; Schweda, Frank ; de Wit, Cor ; Kriz, Wilhelm ; Witzgall, Ralph ; Warth, Richard ; Sauter, Alexander ; Kurtz, Armin ; Wagner, Charlotte

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Date of publication of this fulltext: 05 Aug 2009 13:35

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Abstract

In the adult kidney, renin-producing cells are typically located in the walls of afferent arterioles at the transition into the glomerular capillary network. The mechanisms that are responsible for restricting renin expression to the juxtaglomerular position are largely unknown. This study showed that in mice that lack connexin 40 (Cx40), the predominant connexin of renin-producing cells, ...