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Expression of proteins encoded by Epstein-Barr virus trans-activator genes depends on the differentiation of epithelial cells in oral hairy leukoplakia

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Becker, J. ; Leser, U. ; Marschall, M. ; Langford, A. ; Jilg, Wolfgang ; Gelderblom, H. ; Reichart, P. ; Wolf, Hans J.
Date of publication of this fulltext: 12 Apr 2011 08:00


The Epstein-Barr virus (EBV) immediate early gene product BZLF1 was localized by indirect immunofluorescence to the cytoplasm of the basal epithelial layer at the lateral border and dorsum of tongue in human immunodeficiency virus-infected and -seronegative patients. Two biopsies of oral hairy leukoplakia revealed a sporadic cytoplasmic staining of the BHRF1 and BRLF1 gene products in the basal ...


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