Modification of HLA expression as a possible factor in the pathogenesis of Burkitt's lymphoma

URN zum Zitieren dieses Dokuments: urn:nbn:de:bvb:355-epub-205205

Voltz, R., Jilg, Wolfgang und Wolf, Hans J. (1989) Modification of HLA expression as a possible factor in the pathogenesis of Burkitt's lymphoma. In: Neth, Rolf, (ed.) Modern trends in human leukemia VIII : new results in clinical and biological research including pediatric oncology. Haematology and blood transfusion, 32. Springer, Berlin. ISBN 3-540-50967-4, 0-387-50967-4.

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Our data show that: Most BL cells express significantly less HLA class I and II than the corresponding LCLs. Lymphoblastoid cell lines have a much higher HLA class I and II density than normal peripheral blood B cells. There are qualitative differences in class I and II expression in most BL/LCL pairs. These qualitative differences are not caused by EBV infection. They might be due to a selective ...

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