Voltz, R., Jilg, Wolfgang und Wolf, Hans J.
(1989)
Modification of HLA expression as a possible factor in the pathogenesis of Burkitt's lymphoma.
In: Neth, Rolf, (ed.)
Modern trends in human leukemia VIII : new results in clinical and biological research including pediatric oncology.
Haematology and blood transfusion, 32.
Springer, Berlin.
ISBN 3-540-50967-4, 0-387-50967-4.
Veröffentlichungsdatum dieses Volltextes: 18 Apr 2011 11:31Zum PubMed-Eintrag dieses Artikels
Zusammenfassung
Our data show that: Most BL cells express significantly less HLA class I and II than the corresponding LCLs. Lymphoblastoid cell lines have a much higher HLA class I and II density than normal peripheral blood B cells. There are qualitative differences in class I and II expression in most BL/LCL pairs. These qualitative differences are not caused by EBV infection. They might be due to a selective ...
Zusammenfassung
Our data show that: Most BL cells express significantly less HLA class I and II than the corresponding LCLs. Lymphoblastoid cell lines have a much higher HLA class I and II density than normal peripheral blood B cells. There are qualitative differences in class I and II expression in most BL/LCL pairs. These qualitative differences are not caused by EBV infection. They might be due to a selective downregulation of HLA specifities by c-myc activation. We conclude that these modifications of HLA expression may well play a role in the reduced specific immune recognition of Burkitt's lymphoma cells.
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