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Modular Synthesis of Triazole-Containing Triaryl α-Helix Mimetics

Ehlers, I., Maity, P., Aube, J. and König, Burkhard (2011) Modular Synthesis of Triazole-Containing Triaryl α-Helix Mimetics. European Journal of Organic Chemistry, pp. 2474-2490.

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We describe novel scaffold designs for nonpeptidic α-helix mimetics. The tricyclic scaffolds contain triazoles and reproduce amino acid side chains i, i+3, and i+7. The three different scaffolds are synthetically readily accessible, allow the introduction of further substituents to increase the versatility,and are suitable for library design. A modular synthesis route using Cu I- and Ru ...


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Item type:Article
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König
Projects:GRK 760, Graduiertenkolleg Medizinische Chemie
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Keywords:Helical structures / Peptidomimetics / Click chemistry / Nitrogen heterocycles / Protein-protein interactions
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:20613
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