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Determination of oxygen gradients in engineered tissue using a fluorescent sensor

DOI to cite this document:
10.5283/epub.20853
Kellner, Karin ; Liebsch, Gregor ; Klimant, Ingo ; Wolfbeis, Otto S. ; Blunk, Torsten ; Schulz, Michaela B. ; Göpferich, Achim
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Date of publication of this fulltext: 20 May 2011 06:27


Abstract

Nutrient and oxygen supply of cells are crucial to tissue engineering in general. If a sufficient supply cannot be maintained, the development of the tissue will slow down or even fail completely. Previous studies on oxygen supply have focused on measurement of oxygen partial pressures (pO(2)) in culture media or described the use of invasive techniques with spatially limited resolution. The ...

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