DR2-positive monozygotic twins discordant for narcolepsy

URN to cite this document:: urn:nbn:de:bvb:355-epub-209133
DOI to cite this document:: 10.5283/epub.20913

Pollmächer, T. ; Schulz, H. ; Geisler, Peter ; Kiss, E. ; Albert, E. D. ; Schwarzfischer, F.

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Date of publication of this fulltext: 23 May 2011 06:31

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Abstract

Narcolepsy runs in families, and recent research has revealed the human leukocyte antigen (HLA) DR2 to be a genetic marker closely associated with the disease. But, as indicated by family studies, other factors contribute to the pathogenesis of narcolepsy. The investigation of monozygotic twins is the most specific research tool for distinguishing between a multigenetic and a multifactorial ...