The antiapoptotic gene survivin is highly expressed in human chondrosarcoma and promotes drug resistance in chondrosarcoma cells in vitro

URN to cite this document:: urn:nbn:de:bvb:355-epub-209769
DOI to cite this document:: 10.5283/epub.20976

Lechler, Philipp ; Renkawitz, Tobias ; Campean, Valentina ; Balakrishnan, Sanjeevi ; Tingart, Markus ; Grifka, Joachim ; Schaumburger, Jens

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Date of publication of this fulltext: 25 May 2011 09:59

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Abstract

Background: Chondrosarcoma is virtually resistant to chemotherapy and radiation therapy. Survivin, the smallest member of the inhibitor of apoptosis protein family, is a critical factor for tumor progression and resistance to conventional therapeutic approaches in a wide range of malignancies. However, the role of survivin in chondrosarcoma has not been well studied. We examined the importance of ...