Optimization of capacitive affinity sensors: drift suppression and signal amplification

DOI to cite this document:: 10.5283/epub.21006

Riepl, Michael ; Mirsky, Vladimir M. ; Novotny, Ivan ; Tvarozek, Vladimir ; Rehacek, Vlastimil ; Wolfbeis, Otto S.

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Date of publication of this fulltext: 06 Jun 2011 13:36

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Item type:	Article
Journal or Publication Title:	Analytica Chimica Acta
Publisher:	Elsevier
Volume:	392
Page Range:	pp. 77-84
Date:	1999
Institutions:	Chemistry and Pharmacy > Institut für Analytische Chemie, Chemo- und Biosensorik > Chemo- und Biosensorik (Prof. Antje J. Bäumner, formerly Prof. Wolfbeis)
Keywords:	Affinity sensor; Self-assembly; Capacitive sensor; Signal amplification; Immunosensor; Biosensor
Dewey Decimal Classification:	500 Science > 540 Chemistry & allied sciences
Status:	Published
Refereed:	Unknown
Created at the University of Regensburg:	Unknown
Item ID:	21006

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Abstract

The detection limit of capacitive affinity sensors based on the gold±alkanethiol system can be improved by optimization of sensor preparation and by signal amplification. The dissociation of the gold±sulfur binding is often a critical point leading to operative errors of such sensors. The stability of self-assembled monolayers prepared with different thiols on gold electrodes in aqueous and ...

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