Cell-type Specific Protoporphyrin IX Metabolism in Human Bladder Cancer in vitro

DOI to cite this document:: 10.5283/epub.21084

Krieg, Rene C. ; Fickweiler, Sonja ; Wolfbeis, Otto S. ; Knuechel, Ruth

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Date of publication of this fulltext: 06 Jun 2011 12:37

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Abstract

5-Aminolevulinic acid (ALA)–supported fluorescence endoscopy of the urinary bladder results in a detection rate of bladder cancer superior to that of white light endoscopy. The different accumulation of the metabolite protoporphyrin IX (PPIX) in tumor cells after ALA instillation is poorly understood; however, it is crucial to optimize diagnosis and potential phototherapy. For systematic analysis ...