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Prefrontal dopamine and the dynamic control of human long-term memory

Wimber, Maria ; Schott, Björn H. ; Wendler, Franziska ; Seidenbecher, Constanze I. ; Behnisch, Gusalija ; Macharadze, Tamar ; Bäuml, Karl-Heinz T. ; Richardson-Klavehn, Alan


Abstract

Dopaminergic projections to the prefrontal cortex support higher-order cognitive functions, and are critically involved in many psychiatric disorders that involve memory deficits, including schizophrenia. The role of prefrontal dopamine in long-term memory, however, is still unclear. We used an imaging genetics approach to examine the hypothesis that dopamine availability in the prefrontal cortex ...

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