Dummer, R. ; Miller, K. ; Eilles, Christoph ; Burg, G.
Alternative Links zum Volltext:DOI
| Dokumentenart: | Artikel |
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| Titel eines Journals oder einer Zeitschrift: | Dermatologica |
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| Verlag: | Karger |
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| Band: | 183 |
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| Nummer des Zeitschriftenheftes oder des Kapitels: | 2 |
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| Seitenbereich: | S. 95-99 |
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| Datum: | 1991 |
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| Institutionen: | Medizin > Abteilung für Nuklearmedizin |
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| Identifikationsnummer: | | Wert | Typ |
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| DOI: 10.1159/000247645 | DOI |
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| Stichwörter / Keywords: | Interleukin-2; Immunotherapy; Side effects; Interferon-γ: Tumor necrosis factor α |
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| Dewey-Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin |
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| Status: | Veröffentlicht |
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| Begutachtet: | Unbekannt / Keine Angabe |
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| An der Universität Regensburg entstanden: | Unbekannt / Keine Angabe |
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| Dokumenten-ID: | 21148 |
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Zusammenfassung
Six patients with metastatic malignant melanoma were treated systemically with dacarbazine and interleu-kin-2 (IL-2). During IL-2 administration all patients developed a macular erythematousrash followed by scaling which began 24–48 h after IL-2 infusion. The dermatological changes were associated with elevated interferon-γ and tumor necrosis factor α serum levels (immunoradiometric assay). ...
Zusammenfassung
Six patients with metastatic malignant melanoma were treated systemically with dacarbazine and interleu-kin-2 (IL-2). During IL-2 administration all patients developed a macular erythematousrash followed by scaling which began 24–48 h after IL-2 infusion. The dermatological changes were associated with elevated interferon-γ and tumor necrosis factor α serum levels (immunoradiometric assay). Histology revealed nonspecific spongiotic foci in the epidermis and a perivascular mononuclear infiltrate in the dermis. Immunohistochemistry characterized this infiltrate mainly as activated T helper lymphocytes and revealed the expression of intercellular adhesion molecule 1 by endothelial cells and keratinocytes that might have been induced by interferon-γ. The skin reactions associated with systemic IL-2 administration show that the skin actually participates as a target organ. They should be differentiated from drug eruptions.
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