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Isoniazid protects mice against endotoxin lethality without influencing tumor necrosis factor synthesis and release
Urbaschek, R., Männel, Daniela N. und Urbanczik, R. (1991) Isoniazid protects mice against endotoxin lethality without influencing tumor necrosis factor synthesis and release. Antimicrobial agents and chemotherapy 35 (8), S. 1666-1668.Veröffentlichungsdatum dieses Volltextes: 17 Jun 2011 05:59
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DOI zum Zitieren dieses Dokuments: 10.5283/epub.21166
Zusammenfassung
Treatment of NMRI mice with isoniazid (INH; 25 mg/kg) intraperitoneally induced significant protection when it was injected before or after a lethal intravenous challenge with endotoxin. The INH preparation used was not contaminated with endotoxin. Tumor necrosis factor (TNF) was not elevated in sera from NMRI mice 2 h after the injection of INH. INH did not influence TNF synthesis or release ...
Treatment of NMRI mice with isoniazid (INH; 25 mg/kg) intraperitoneally induced significant protection when it was injected before or after a lethal intravenous challenge with endotoxin. The INH preparation used was not contaminated with endotoxin. Tumor necrosis factor (TNF) was not elevated in sera from NMRI mice 2 h after the injection of INH. INH did not influence TNF synthesis or release determined in human monocytes in vitro. Therefore, it is concluded that the protective effect of INH against lethal endotoxin is not due to a suppressive effect of INH on TNF production.
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| Dokumentenart | Artikel | ||||||||||||||||||||||
| Titel eines Journals oder einer Zeitschrift | Antimicrobial agents and chemotherapy | ||||||||||||||||||||||
| Verlag: | American Society for Microbiology | ||||||||||||||||||||||
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| Band: | 35 | ||||||||||||||||||||||
| Nummer des Zeitschriftenheftes oder des Kapitels: | 8 | ||||||||||||||||||||||
| Seitenbereich: | S. 1666-1668 | ||||||||||||||||||||||
| Datum | 1991 | ||||||||||||||||||||||
| Institutionen | Medizin > Lehrstuhl für Immunologie | ||||||||||||||||||||||
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| Dewey-Dezimal-Klassifikation | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin | ||||||||||||||||||||||
| Status | Veröffentlicht | ||||||||||||||||||||||
| Begutachtet | Ja, diese Version wurde begutachtet | ||||||||||||||||||||||
| An der Universität Regensburg entstanden | Unbekannt / Keine Angabe | ||||||||||||||||||||||
| URN der UB Regensburg | urn:nbn:de:bvb:355-epub-211666 | ||||||||||||||||||||||
| Dokumenten-ID | 21166 |
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