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Isoniazid protects mice against endotoxin lethality without influencing tumor necrosis factor synthesis and release
Urbaschek, R., Männel, Daniela N. and Urbanczik, R. (1991) Isoniazid protects mice against endotoxin lethality without influencing tumor necrosis factor synthesis and release. Antimicrobial agents and chemotherapy 35 (8), pp. 1666-1668.Date of publication of this fulltext: 17 Jun 2011 05:59
Article
DOI to cite this document: 10.5283/epub.21166
Abstract
Treatment of NMRI mice with isoniazid (INH; 25 mg/kg) intraperitoneally induced significant protection when it was injected before or after a lethal intravenous challenge with endotoxin. The INH preparation used was not contaminated with endotoxin. Tumor necrosis factor (TNF) was not elevated in sera from NMRI mice 2 h after the injection of INH. INH did not influence TNF synthesis or release ...
Treatment of NMRI mice with isoniazid (INH; 25 mg/kg) intraperitoneally induced significant protection when it was injected before or after a lethal intravenous challenge with endotoxin. The INH preparation used was not contaminated with endotoxin. Tumor necrosis factor (TNF) was not elevated in sera from NMRI mice 2 h after the injection of INH. INH did not influence TNF synthesis or release determined in human monocytes in vitro. Therefore, it is concluded that the protective effect of INH against lethal endotoxin is not due to a suppressive effect of INH on TNF production.
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| Item type | Article | ||||||||||||||||||||||
| Journal or Publication Title | Antimicrobial agents and chemotherapy | ||||||||||||||||||||||
| Publisher: | American Society for Microbiology | ||||||||||||||||||||||
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| Volume: | 35 | ||||||||||||||||||||||
| Number of Issue or Book Chapter: | 8 | ||||||||||||||||||||||
| Page Range: | pp. 1666-1668 | ||||||||||||||||||||||
| Date | 1991 | ||||||||||||||||||||||
| Institutions | Medicine > Lehrstuhl für Immunologie | ||||||||||||||||||||||
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| Dewey Decimal Classification | 600 Technology > 610 Medical sciences Medicine | ||||||||||||||||||||||
| Status | Published | ||||||||||||||||||||||
| Refereed | Yes, this version has been refereed | ||||||||||||||||||||||
| Created at the University of Regensburg | Unknown | ||||||||||||||||||||||
| URN of the UB Regensburg | urn:nbn:de:bvb:355-epub-211666 | ||||||||||||||||||||||
| Item ID | 21166 |
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