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Isoniazid protects mice against endotoxin lethality without influencing tumor necrosis factor synthesis and release

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Urbaschek, R. ; Männel, Daniela N. ; Urbanczik, R.
Date of publication of this fulltext: 17 Jun 2011 05:59


Treatment of NMRI mice with isoniazid (INH; 25 mg/kg) intraperitoneally induced significant protection when it was injected before or after a lethal intravenous challenge with endotoxin. The INH preparation used was not contaminated with endotoxin. Tumor necrosis factor (TNF) was not elevated in sera from NMRI mice 2 h after the injection of INH. INH did not influence TNF synthesis or release ...


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