Isoniazid protects mice against endotoxin lethality without influencing tumor necrosis factor synthesis and release

URN to cite this document:: urn:nbn:de:bvb:355-epub-211666
DOI to cite this document:: 10.5283/epub.21166

Urbaschek, R. ; Männel, Daniela N. ; Urbanczik, R.

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Date of publication of this fulltext: 17 Jun 2011 05:59

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Abstract

Treatment of NMRI mice with isoniazid (INH; 25 mg/kg) intraperitoneally induced significant protection when it was injected before or after a lethal intravenous challenge with endotoxin. The INH preparation used was not contaminated with endotoxin. Tumor necrosis factor (TNF) was not elevated in sera from NMRI mice 2 h after the injection of INH. INH did not influence TNF synthesis or release ...