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Regulation of TNF-alpha, IL-1 and IL-6 synthesis in differentiating human monoblastoid leukemic U937 cells

Hass, R., Lonnemann, G., Männel, Daniela N., Topley, N., Hartmann, A., Köhler, L., Resch, K. and Goppelt-Strübe, M. (1991) Regulation of TNF-alpha, IL-1 and IL-6 synthesis in differentiating human monoblastoid leukemic U937 cells. Leukemia research 15 (5), pp. 327-339.

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Date of publication of this fulltext: 20 Jun 2011 06:18

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Abstract

The human monoblastoid tumor cell line U937 was induced to differentiate along the monocyte/macrophage lineage by treatment with 5 x 10(-9) M 12-O-tetradecanoyl phorbol-13-acetate (TPA). Between 2 h and 4 h following TPA-treatment U937 cells started to release significant amounts of TNF-alpha which remained detectable until 8-10 days. A significant IL-1 beta release was measured 24 h-48 h post ...

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Item type:Article
Date:1991
Institutions:Medicine > Lehrstuhl für Immunologie
Identification Number:
ValueType
1904515PubMed ID
Classification:
NotationType
Blotting, NorthernMESH
Cell Differentiation/drug effectsMESH
Cell LineMESH
Dinoprostone/pharmacologyMESH
HumansMESH
Interferon-gamma, Recombinant/pharmacologyMESH
Interleukin-1/geneticsMESH
Interleukin-6/geneticsMESH
KineticsMESH
Leukemia, Monocytic, AcuteMESH
RNA, Messenger/geneticsMESH
Recombinant Proteins/pharmacologyMESH
Tetradecanoylphorbol Acetate/pharmacologyMESH
Tumor Necrosis Factor-alpha/pharmacologyMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:21168
Owner only: item control page

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