Ho, A. D., Männel, Daniela N., Wulf, G., Kirchner, H., Gundt, A., Trede, I., Rensch, K. und Hunstein, W.
(1990)
Long-term effects of 2'-deoxycoformycin treatment on cytokine production in patients with hairy cell leukemia.
Leukemia 4 (8), S. 584-589.
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Zusammenfassung
Deoxycoformycin (DCF) has been reported to cause immediate reduction and dysfunction of T lymphocytes, but the long-term effects on immune functions are still not known. As cytokine production is regulated by T helper-inducer lymphocytes and might represent a parameter for functional integrity of immunocompetent cells, we have measured the production of interleukin-2 (IL-2), tumor necrosis factor ...
Zusammenfassung
Deoxycoformycin (DCF) has been reported to cause immediate reduction and dysfunction of T lymphocytes, but the long-term effects on immune functions are still not known. As cytokine production is regulated by T helper-inducer lymphocytes and might represent a parameter for functional integrity of immunocompetent cells, we have measured the production of interleukin-2 (IL-2), tumor necrosis factor (TNF), and interferons (IFN) by peripheral mononuclear cells (PMNC) from 10 patients with hairy cell leukemia 11-24 months after end of therapy with DCF. The patients were in continuous remission at the time of study. Despite an absolute reduction in CD3+ and CD4+ lymphocytes. there were no significant differences in IL-2 or TNF release between patients and controls. Except for a significant reduction in IFN-alpha release stimulated by Newcastle disease virus (NDV), IFN productions induced by other mitogens (phytohemagglutinin, PHA; Concanavalin A, ConA; pokeweed mitogen, PWM) and viral antigens were within normal range. There was also a decrease in proliferative responsiveness to PHA, but responses to ConA, PWM, and other viral antigens were normal. In five of the patients, we have monitored closely the changes in IL-2, TNF, and IFN before, during, and after treatment and could demonstrate a rapid normalization of initially decreased IL-2 release in all cases and also of TNF if the initial production was reduced. This study shows that, even though the absolute number of T lymphocytes and helper cells are reduced in the long-term observation after DCF treatment, the capacity to produce IL-2, TNF, and IFN-gamma was within normal range. Parallel to this observation, no opportunistic infections or frequency of infectious complications occurred in these patients.
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| Dokumentenart: | Artikel |
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| Datum: | 1990 |
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| Institutionen: | Medizin > Lehrstuhl für Immunologie |
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| Identifikationsnummer: | |
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| Klassifikation: | | Notation | Art |
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| Adult | MESH | | Aged | MESH | | Female | MESH | | Humans | MESH | | Interferons/biosynthesis | MESH | | Interleukin-2/biosynthesis | MESH | | Leukemia, Hairy Cell/metabolism | MESH | | Leukocyte Count/drug effects | MESH | | Leukocytes, Mononuclear/metabolism | MESH | | Male | MESH | | Middle Aged | MESH | | Pentostatin/therapeutic use | MESH | | Remission Induction | MESH | | T-Lymphocytes/drug effects | MESH | | Time Factors | MESH | | Tumor Necrosis Factor-alpha/biosynthesis | MESH |
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| Dewey-Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin |
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| Status: | Veröffentlicht |
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| Begutachtet: | Ja, diese Version wurde begutachtet |
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| An der Universität Regensburg entstanden: | Unbekannt / Keine Angabe |
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| Dokumenten-ID: | 21172 |
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