Ho, A. D., Männel, Daniela N., Wulf, G., Kirchner, H., Gundt, A., Trede, I., Rensch, K. and Hunstein, W.
(1990)
Long-term effects of 2'-deoxycoformycin treatment on cytokine production in patients with hairy cell leukemia.
Leukemia 4 (8), pp. 584-589.
Full text not available from this repository.
at PubMed
Abstract
Deoxycoformycin (DCF) has been reported to cause immediate reduction and dysfunction of T lymphocytes, but the long-term effects on immune functions are still not known. As cytokine production is regulated by T helper-inducer lymphocytes and might represent a parameter for functional integrity of immunocompetent cells, we have measured the production of interleukin-2 (IL-2), tumor necrosis factor ...
Abstract
Deoxycoformycin (DCF) has been reported to cause immediate reduction and dysfunction of T lymphocytes, but the long-term effects on immune functions are still not known. As cytokine production is regulated by T helper-inducer lymphocytes and might represent a parameter for functional integrity of immunocompetent cells, we have measured the production of interleukin-2 (IL-2), tumor necrosis factor (TNF), and interferons (IFN) by peripheral mononuclear cells (PMNC) from 10 patients with hairy cell leukemia 11-24 months after end of therapy with DCF. The patients were in continuous remission at the time of study. Despite an absolute reduction in CD3+ and CD4+ lymphocytes. there were no significant differences in IL-2 or TNF release between patients and controls. Except for a significant reduction in IFN-alpha release stimulated by Newcastle disease virus (NDV), IFN productions induced by other mitogens (phytohemagglutinin, PHA; Concanavalin A, ConA; pokeweed mitogen, PWM) and viral antigens were within normal range. There was also a decrease in proliferative responsiveness to PHA, but responses to ConA, PWM, and other viral antigens were normal. In five of the patients, we have monitored closely the changes in IL-2, TNF, and IFN before, during, and after treatment and could demonstrate a rapid normalization of initially decreased IL-2 release in all cases and also of TNF if the initial production was reduced. This study shows that, even though the absolute number of T lymphocytes and helper cells are reduced in the long-term observation after DCF treatment, the capacity to produce IL-2, TNF, and IFN-gamma was within normal range. Parallel to this observation, no opportunistic infections or frequency of infectious complications occurred in these patients.
Export bibliographical data
| Item type: | Article |
|---|
| Date: | 1990 |
|---|
| Institutions: | Medicine > Lehrstuhl für Immunologie |
|---|
| Identification Number: | | Value | Type |
|---|
| 1697012 | PubMed ID |
|
|---|
| Classification: | | Notation | Type |
|---|
| Adult | MESH | | Aged | MESH | | Female | MESH | | Humans | MESH | | Interferons/biosynthesis | MESH | | Interleukin-2/biosynthesis | MESH | | Leukemia, Hairy Cell/metabolism | MESH | | Leukocyte Count/drug effects | MESH | | Leukocytes, Mononuclear/metabolism | MESH | | Male | MESH | | Middle Aged | MESH | | Pentostatin/therapeutic use | MESH | | Remission Induction | MESH | | T-Lymphocytes/drug effects | MESH | | Time Factors | MESH | | Tumor Necrosis Factor-alpha/biosynthesis | MESH |
|
|---|
| Dewey Decimal Classification: | 600 Technology > 610 Medical sciences Medicine |
|---|
| Status: | Published |
|---|
| Refereed: | Yes, this version has been refereed |
|---|
| Created at the University of Regensburg: | Unknown |
|---|
| Item ID: | 21172 |
|---|
Altmetric