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Long-term effects of 2'-deoxycoformycin treatment on cytokine production in patients with hairy cell leukemia

Ho, A. D. ; Männel, Daniela N. ; Wulf, G. ; Kirchner, H. ; Gundt, A. ; Trede, I. ; Rensch, K. ; Hunstein, W.


Deoxycoformycin (DCF) has been reported to cause immediate reduction and dysfunction of T lymphocytes, but the long-term effects on immune functions are still not known. As cytokine production is regulated by T helper-inducer lymphocytes and might represent a parameter for functional integrity of immunocompetent cells, we have measured the production of interleukin-2 (IL-2), tumor necrosis factor ...


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