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Distinct tumor cell membrane constituents activate human monocytes for tumor necrosis factor synthesis

URN to cite this document:
urn:nbn:de:bvb:355-epub-211731
Jänicke, R. ; Männel, Daniela N.
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Date of publication of this fulltext: 20 Jun 2011 06:20


Abstract

Several lines of evidence point to an activation mechanism of monocytes/macrophages by tumor cells. In this study we present data for distinct surface structures on K562 and Jurkat cells to directly induce TNF-mRNA expression and TNF production by human peripheral blood monocytes. Northern analysis showed that incubation of monocytes with either K562 or Jurkat cells led to a significant increase ...

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