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Tumor necrosis factor induced stimulation of granulopoiesis and radioprotection

Urbaschek, R. ; Männel, Daniela N. ; Urbaschek, B.


Human recombinant tumor necrosis factor, TNF, was used to assess its ability to stimulate granulopoiesis and to protect mice against lethal irradiation, effects known to be inducable with TNF-rich postendotoxin serum from BCG infected mice (BCG/ET serum). Although the endotoxin contamination of this TNF preparation is extremely low its effects were compared in endotoxin low responder C3H/HeJ mice ...


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