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Autocrine stimulation of TNF-alpha mRNA expression in HL-60 cells

Hensel, G. ; Männel, Daniela N. ; Pfizenmaier, K. ; Krönke, M.


We have employed a human promyelocytic leukemic cell line, HL-60, to investigate the conditions that regulate TNF-alpha gene expression in vitro. Using a cloned TNF-alpha specific cDNA probe, we show by Northern blot analysis that TNF-alpha mRNA rapidly accumulates in HL-60 cells following treatment with phorbol myristate acetate (PMA). TNF-alpha mRNA levels peak at 1-2 hours and then decline to ...


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