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Single- and dual- near-infrared fluorescent labeled nucleic acid conjugate for nucleic acid detection

Lin, Zhihong ; Wu, Meng ; Ren, Shu ; Arbter, Michaela ; Boehmer, Martin ; Mirsky, Vladimir ; Wolfbeis, Otto S.


In this research, a near-IR fluorescent labeled nucleic acid conjugate for the nucleic acid detection was synthesized, and characterized preliminarily for the detection of the nucleic acid. Th conjugate combines the molecular recognition properties of the oligonucleotides with the near-IR fluorescence label PR646. Both single- and dual- labeled conjugates were studied for their hybridization with ...


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