Time sequence of histamine release and formation in rat endotoxic shock

URN to cite this document:: urn:nbn:de:bvb:355-epub-217517
DOI to cite this document:: 10.5283/epub.21751

Neugebauer, E. ; Rixen, D. ; Garcia-Caballero, M. ; Scheid, B. ; Lorenz, Wilfried

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Date of publication of this fulltext: 16 Aug 2011 11:46

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Abstract

Increased histamine release and formation (induced histamine) are two hypotheses considered in the pathogenesis of endotoxic shock development. To prove both hypotheses a sequence of four randomized controlled studies in rats was performed. Histamine release was measured indirectly as a decrease in tissue-histamine contents (lung, liver, spleen, stomach); histamine formation was estimated ...