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Time sequence of histamine release and formation in rat endotoxic shock

URN to cite this document:
urn:nbn:de:bvb:355-epub-217517
Neugebauer, E. ; Rixen, D. ; Garcia-Caballero, M. ; Scheid, B. ; Lorenz, Wilfried
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Date of publication of this fulltext: 16 Aug 2011 11:46


Abstract

Increased histamine release and formation (induced histamine) are two hypotheses considered in the pathogenesis of endotoxic shock development. To prove both hypotheses a sequence of four randomized controlled studies in rats was performed. Histamine release was measured indirectly as a decrease in tissue-histamine contents (lung, liver, spleen, stomach); histamine formation was estimated ...

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