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Chronic lymphocytic leukemia cells induce anti-apoptotic effects of bone marrow stroma

Plander, Mark, Ugocsai, Peter, Seegers, Silvia, Orso, Evelyn, Reichle, Albrecht, Schmitz, Gerd, Hofstädter, Ferdinand and Brockhoff, Gero (2011) Chronic lymphocytic leukemia cells induce anti-apoptotic effects of bone marrow stroma. Annals of Hematology.

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Other URL: http://www.springerlink.com/content/ru2584446173w32r/


The prolonged life span of chronic lymphocytic leukemia (CLL) cells in vivo is assumed to depend on the surrounding microenvironment since this biologic feature is lost in vitro. We studied here the molecular interactions between CLL cells and their surrounding stroma to identify factors that help CLL cells to resist apoptosis. Sorted CLL cells from 21 patients were cultured in vitro on ...


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Item type:Article
Date:5 April 2011
Institutions:Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin
Medicine > Lehrstuhl für Pathologie
Identification Number:
Keywords:Chronic lymphocytic leukemia – Apoptosis – Stroma – CD49d – IL-8
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:21777
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