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Chronic lymphocytic leukemia cells induce anti-apoptotic effects of bone marrow stroma

Plander, Mark ; Ugocsai, Peter ; Seegers, Silvia ; Orso, Evelyn ; Reichle, Albrecht ; Schmitz, Gerd ; Hofstädter, Ferdinand ; Brockhoff, Gero


The prolonged life span of chronic lymphocytic leukemia (CLL) cells in vivo is assumed to depend on the surrounding microenvironment since this biologic feature is lost in vitro. We studied here the molecular interactions between CLL cells and their surrounding stroma to identify factors that help CLL cells to resist apoptosis. Sorted CLL cells from 21 patients were cultured in vitro on ...


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