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Significance of histamine formation and release in the development of endotoxic shock: proof of current concepts by randomized controlled studies in rats

Neugebauer, E. ; Lorenz, Wilfried ; Beckurts, T. ; Maroske, D. ; Merte, H.


The significance of histamine in the initiation and progression of septic (endotoxic) shock is still uncertain. Increased new formation and increased release of histamine are the two hypotheses currently considered as the basis for a causal relationship. Both hypotheses were tested in a standardized rat model of endotoxic shock. Several randomized controlled studies were performed with inhibitors ...


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