The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1

URN to cite this document:: urn:nbn:de:bvb:355-epub-219674
DOI to cite this document:: 10.5283/epub.21967

Felle, Max ; Joppien, Saskia ; Németh, Attila ; Diermeier, Sarah

; Thalhammer, Verena ; Dobner, Thomas ; Kremmer, Elisabeth ; Kappler, Roland

; Längst, Gernot

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Date of publication of this fulltext: 31 Aug 2011 10:08

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Abstract

Aberrant DNA methylation is often associated with cancer and the formation of tumors; however, the underlying mechanisms, in particular the recruitment and regulation of DNA methyltransferases remain largely unknown. In this study, we identified USP7 as an interaction partner of Dnmt1 and UHRF1 in vivo. Dnmt1 and USP7 formed a soluble dimer complex that associated with UHRF1 as a trimeric complex ...