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Role of cation gradients in hypercontracture of myocytes during simulated ischemia and reperfusion

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Nishida, M. ; Borzak, S. ; Krämer, Bernhard K. ; Navas, J. P. ; Kelly, R. A. ; Smith, T. W. ; Marsh, J. D.
Date of publication of this fulltext: 12 Sep 2011 08:41


We examined the relationship between transsarcolemmal cation gradients and hypercontracture of cardiac myocytes in ischemia and reperfusion using adult rat ventricular myocytes superfused with buffer mimicking normal or ischemic extracellular fluid. Contractile performance of electrically stimulated cells was recorded by an optical video system simultaneously with measurements of intracellular ...


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