Understanding tumor heterogeneity as functional compartments--superorganisms revisited

URN to cite this document:: urn:nbn:de:bvb:355-epub-221425
DOI to cite this document:: 10.5283/epub.22142

Grunewald, Thomas G. P.

; Herbst, Saskia M. ; Heinze, Jürgen ; Burdach, Stefan

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Date of publication of this fulltext: 26 Sep 2011 09:37

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Abstract

Compelling evidence broadens our understanding of tumors as highly heterogeneous populations derived from one common progenitor. In this review we portray various stages of tumorigenesis, tumor progression, self-seeding and metastasis in analogy to the superorganisms of insect societies to exemplify the highly complex architecture of a neoplasm as a system of functional "castes." Accordingly, we ...