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Understanding tumor heterogeneity as functional compartments--superorganisms revisited

URN to cite this document:
urn:nbn:de:bvb:355-epub-221425
Grunewald, Thomas G. P. ; Herbst, Saskia M. ; Heinze, Jürgen ; Burdach, Stefan
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Date of publication of this fulltext: 26 Sep 2011 09:37


Abstract

Compelling evidence broadens our understanding of tumors as highly heterogeneous populations derived from one common progenitor. In this review we portray various stages of tumorigenesis, tumor progression, self-seeding and metastasis in analogy to the superorganisms of insect societies to exemplify the highly complex architecture of a neoplasm as a system of functional "castes."Accordingly, we ...

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