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Curcumin is a potent modulator of microglial gene expression and migration

URN to cite this document:
urn:nbn:de:bvb:355-epub-224184
Karlstetter, Marcus ; Lippe, Elena ; Walczak, Yana ; Moehle, Christoph ; Aslanidis, Alexander ; Mirza, Myriam ; Langmann, Thomas
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Date of publication of this fulltext: 19 Oct 2011 10:31


Abstract

Background Microglial cells are important effectors of the neuronal innate immune system with a major role in chronic neurodegenerative diseases. Curcumin, a major component of tumeric, alleviates pro-inflammatory activities of these cells by inhibiting nuclear factor kappa B (NFkB) signaling. To study the immuno-modulatory effects of curcumin on a transcriptomic level, DNA-microarray analyses ...

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