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Endothelium-dependent vasoconstriction in isolated vessel grafts: a novel mechanism of vasospasm?

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Hoenicka, Markus ; Keyser, Andreas ; Rupprecht, Leopold ; Puehler, Thomas ; Hirt, Stephan ; Schmid, Christof
Date of publication of this fulltext: 24 Oct 2011 11:41


YC-1-induced vasoconstriction demonstrates the existence of an endothelium-dependent vasoconstrictor pathway in the blood vessels of patients with CAD that to date has been described only in animal models of hypertension. Patients with CAD who have elevated plasma levels of endothelin-1 are thus prone to endothelium-dependent vasoconstriction, which may also play a role in vasospasm in vascular grafts.

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