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Antiviral and Anticoagulant Activities of a Water-Soluble Fraction of the Marine Diatom Haslea ostrearia

Bergé, J.-P. ; Bourgougnon, N. ; Alban, S. ; Pojer, F. ; Billaudel, S. ; Chermann, J.-C. ; Robert, J. M. ; Franz, Gerhard


A water-soluble fraction from the marine diatom Haslea ostrearia was capable to inhibit the in vitro replication of HSV-1 in Vero cells with 50 % inhibitory concentration (EC50) of 14 μg/ml at a multiplicity of infection of 0.01 ID50/cells. In addition, this fraction delayed the HIV-1-induced syncitia formation on MT4 cells. At concentrations up to 200 μg/ml, no cytotoxicity was observed for both ...


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