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Synthesis and binding properties of guanidinium biscarboxylates

Späth, A. ; Gonschor, Janina ; König, Burkhard



Zusammenfassung

The ammonium ion binding site of the enzyme glutaminase HisF inspired us to design guanidinium biscarboxylates as potential self-organized ionophores in molecular recognition. The syntheses of the title compounds based on aliphatic and aromatic building blocks, along with a general method for the preparation of δ-aminoethoxyacetic acids, are presented in this work. Investigation of the binding ...

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