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Anticoagulant sulfated polysaccharides: Part I. Synthesis and structure–activity relationships of new pullulan sulfates

Alban, S. ; Schauerte, A. ; Franz, Gerhard



Abstract

In order to develop new anticoagulants as potential heparin alternatives, two pullulans with different molecular weight (MW) were used as starting polymers for the partial synthesis of a structurally new class of sulfated polysaccharides. Sulfation of these linear α-1,4-/1,6-glucans was carried out by a method with a SO3–pyridine complex in DMF, which had been optimized for the modification of ...

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