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Post-translational modification and regulation of human Spir protein

URN to cite this document:
urn:nbn:de:bvb:355-epub-229606
Lakshmi, Sreeja
Date of publication of this fulltext: 14 Dec 2011 10:33


Abstract (English)

Spir proteins are the primodial members of the emerging group of actin nucleation factors, which initiate actin polymerization by binding monomeric actin to one or multiple Wiskott-Aldrich Syndrome protein (WASp) homology-2 domains. Spir proteins are implicated in diverse cellular processes including actin dynamics, vesicle trafficking as well as Drosophila and mammalian oogenesis. Despite the ...

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Translation of the abstract (German)

Spir Proteine sind primodiale Elemente einer neuen Gruppe von Aktin-Nukleations-Faktoren, die Aktin Polymerisation initiieren, indem sie Aktin Monomere an ein oder mehrere Wiskott- Aldrich-Syndrom Protein Homologie-2 Domänen (WASp) binden. Spir Proteine werden mit diversen zellulären Prozessen in Verbindung gebracht, einschließlich Aktin-Dynamik, Vesikel-Transport und Oogenese in Drosophila und ...

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