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Post-translational modification and regulation of human Spir protein

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Lakshmi, Sreeja
Date of publication of this fulltext: 14 Dec 2011 10:33

Abstract (English)

Spir proteins are the primodial members of the emerging group of actin nucleation factors, which initiate actin polymerization by binding monomeric actin to one or multiple Wiskott-Aldrich Syndrome protein (WASp) homology-2 domains. Spir proteins are implicated in diverse cellular processes including actin dynamics, vesicle trafficking as well as Drosophila and mammalian oogenesis. Despite the ...


Translation of the abstract (German)

Spir Proteine sind primodiale Elemente einer neuen Gruppe von Aktin-Nukleations-Faktoren, die Aktin Polymerisation initiieren, indem sie Aktin Monomere an ein oder mehrere Wiskott- Aldrich-Syndrom Protein Homologie-2 Domänen (WASp) binden. Spir Proteine werden mit diversen zellulären Prozessen in Verbindung gebracht, einschließlich Aktin-Dynamik, Vesikel-Transport und Oogenese in Drosophila und ...


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