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Characterization and functional analysis of mouse Ficolin B

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Hunold, Katja
Date of publication of this fulltext: 23 Jan 2012 09:05

Abstract (English)

The innate immune system contributes day by day to the elimination of invading pathogens. The lectin pathway of the complement system is initiated when mannose-binding-lectin (MBL) or ficolins interact with MASP-2. The aim of the present work was to characterize the mouse FcnB and define its function in the innate immune system and especially its role in the complement activation. Results from ...


Translation of the abstract (German)

Das angeborene Immunsystem trägt Tag für Tag dazu bei, eindringende Pathogene zu beseitigen. Der Lektin-Weg des Komplement Systems wird eingeleitet wenn Mannose-Binding-Lektin (MBL) oder Ficoline mit MASP-2 interagieren. Das Ziel der vorliegenden Arbeit war die Charakterisierung von Maus-Ficolin-B und das Bestimmen seiner Funktion im angeborenen Immunsystem, insbesondere seine Rolle in der ...


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