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Biodegradable hydrogels for time-controlled release of tethered peptides or proteins

Brandl, Ferdinand ; Hammer, Nadine ; Blunk, Torsten ; Teßmar, Jörg ; Göpferich, Achim


Tethering drug substances to a gel network is an effective way of controlling the release kinetics of hydrogel-based drug delivery systems. Here, we report on in situ forming, biodegradable hydrogels that allow for the covalent attachment of peptides or proteins. Hydrogels were prepared by step-growth polymerization of branched poly(ethylene glycol). The gel strength ranged from 1075 to 2435 Pa; ...


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