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Biodegradable hydrogels for time-controlled release of tethered peptides or proteins

Brandl, Ferdinand, Hammer, Nadine, Blunk, Torsten, Teßmar, Jörg and Göpferich, Achim (2010) Biodegradable hydrogels for time-controlled release of tethered peptides or proteins. Biomacromolecules 11 (2), pp. 496-504.

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Tethering drug substances to a gel network is an effective way of controlling the release kinetics of hydrogel-based drug delivery systems. Here, we report on in situ forming, biodegradable hydrogels that allow for the covalent attachment of peptides or proteins. Hydrogels were prepared by step-growth polymerization of branched poly(ethylene glycol). The gel strength ranged from 1075 to 2435 Pa; ...


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Item type:Article
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich)
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Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
600 Technology > 615 Pharmacy
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:23230
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