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Alkylcyanoacrylate drug carriers: I. Physicochemical characterization of nanoparticles with different alkyl chain length

URN to cite this document:
Müller, R. H. ; Lherm, C. ; Herbort, J. ; Blunk, Torsten ; Couvreur, P.
Date of publication of this fulltext: 27 Jan 2012 07:17


Alkylcyanoacrylate particles were physico-chemically characterized in terms of size, surface charge, zeta potential, interaction with charged serum components and surface hydrophobicity as relevant parameters influencing the in vitro interaction with cells in culture and the in vivo organ distribution and fate after intravenous administration. Methyl-, ethyl-, isobutyl- and isohexyl-cyanoacrylate ...


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