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Mechanistic investigation of poly(ethylene imine)-based siRNA delivery: Disulfide bonds boost intracellular release of the cargo

Breunig, Miriam ; Hosza, C. ; Lungwitz, Uta ; Watanabe, K. ; Umeda, I. ; Kato, H. ; Göpferich, Achim



Zusammenfassung

Poly(ethylene imine) (PEI) has gained increasing attention in the delivery of small interfering RNAs (siRNAs) into cells. In order to further optimize PEI for this application, the first goal of this study was to examine particular steps of siRNA delivery with various PEI derivatives as carriers. Furthermore, the hypothesis that disulfide cleavable carrier systems are favorable for the release of ...

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