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Occlusion of regulatory sequences by promoter nucleosomes in vivo

URN to cite this document:
urn:nbn:de:bvb:355-epub-234578
DOI to cite this document:
10.5283/epub.23457
Mao, Changhui ; Brown, Christopher R. ; Griesenbeck, Joachim ; Boeger, Hinrich
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Date of publication of this fulltext: 17 Feb 2012 08:39


Abstract

Nucleosomes are believed to inhibit DNA binding by transcription factors. Theoretical attempts to understand the significance of nucleosomes in gene expression and regulation are based upon this assumption. However, nucleosomal inhibition of transcription factor binding to DNA is not complete. Rather, access to nucleosomal DNA depends on a number of factors, including the stereochemistry of ...

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