Interaction of bestrophin-1 and Ca2+ channel β-subunits: identification of new binding domains on the bestrophin-1 C-terminus.

URN to cite this document:: urn:nbn:de:bvb:355-epub-237514
DOI to cite this document:: 10.5283/epub.23751

Milenkovic, Vladimir M. ; Krejcova, Sarka ; Reichhart, Nadine ; Wagner, Andrea ; Strauss, Olaf

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Date of publication of this fulltext: 11 Apr 2012 09:07

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Abstract

Bestrophin-1 modulates currents through voltage-dependent L-type Ca2+ channels by physically interacting with the beta-subunits of Ca2+ channels. The main function of beta-subunits is to regulate the number of pore-forming Ca-V-subunits in the cell membrane and modulate Ca2+ channel currents. To understand the influence of full-length bestrophin-1 on beta-subunit function, we studied binding and ...