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- URN zum Zitieren dieses Dokuments:
- urn:nbn:de:bvb:355-epub-237897
- DOI zum Zitieren dieses Dokuments:
- 10.5283/epub.23789
Zusammenfassung
HIV-1 candidate vaccines expressing an artificial polyprotein comprising Gag, Pol and Nef (GPN) and a secreted envelope protein (Env) were shown in recent Phase I/II clinical trials to induce high levels of polyfunctional T cell responses; however, Env-specific responses clearly exceeded those against Gag. Here, we assess the impact of the GPN immunogen design and variations in the formulation ...
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