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Increasing capillary diameter and the incorporation of gelatin enhance axon outgrowth in alginate-based anisotropic hydrogels

Pawara, Kiran ; Mueller, Rainer ; Caioni, Massimiliano ; Prang, Peter ; Bogdan, Ulrich ; Kunz, Werner ; Weidner, Norbert



Abstract

Substantial recovery of function following peripheral and central nervous system (CNS) injury critically depends on longitudinally directed axon regeneration across the injury site, which requires a mech. guidance providing scaffold. We have previously shown that anisotropic alginate-based hydrogels with a defined capillary diam. (25 μm), which form via a self-organizing process driven by ...

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