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Influence of surface pretreatment of titanium- and cobalt-based biomaterials on covalent immobilization of fibrillar collagen

Müller, Rainer ; Abke, Jochen ; Schnell, Edith ; Scharnweber, D. ; Kujat, R. ; Englert, Carsten ; Taheri, D. ; Nerlich, Michael ; Angele, Peter


Collagen type-I is a major component of the extracellular matrix of most tissues and it is increasingly utilized for surface engineering of biomaterials to accelerate receptor-mediated cell adhesion. In the present study, coatings with layers of fibrillar type-I collagen were prepd. on titanium, titanium alloy, and cobalt alloy to improve initial osteoblast adhesion and implant-tissue ...


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