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Biochemical actions of l-deprenyl (selegiline)

Lange, Klaus W., Riederer, P. and Youdim, M. B. (1994) Biochemical actions of l-deprenyl (selegiline). Clinical pharmacology and therapeutics 56 (6 Pt 2), pp. 734-741.

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Abstract

l-Deprenyl is a selective, irreversible monoamine oxidase (MAO) type B inhibitor. Dopamine is a relatively good MAO-B substrate in the human brain. Because Parkinson's disease is characterized by a decrease in dopaminergic neurotransmission in the basal ganglia, the selective inhibition of MAO-B should lead to diminished metabolism of dopamine in the nigrostriatal system and a significant ...

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Item type:Article
Date:1994
Institutions:Psychology and Pedagogy > Institut für Psychologie > Lehrstuhl für Psychologie III (Biologische, Klinische und Rehabilitationspsychologie) - Prof. Dr. Klaus W. Lange
Identification Number:
ValueType
7995015PubMed ID
10.1038/clpt.1994.203DOI
Classification:
NotationType
AnimalsMESH
Autonomic Nervous System/drug effectsMESH
Enzyme Induction/drug effectsMESH
HumansMESH
Oxidation-Reduction/drug effectsMESH
Parkinson Disease/drug therapyMESH
Receptors, N-Methyl-D-Aspartate/drug effectsMESH
Selegiline/pharmacologyMESH
Superoxide Dismutase/biosynthesisMESH
Dewey Decimal Classification:100 Philosophy & psychology > 150 Psychology
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:25414
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