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Glutamatergic drugs in Parkinson's disease

URN to cite this document:
urn:nbn:de:bvb:355-epub-254180
Lange, Klaus W. ; Riederer, Peter
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Date of publication of this fulltext: 19 Jul 2012 07:56


Abstract

Recent findings in monkeys indicate that excitatory amino acids such as glutamate are involved in the pathophysiological cascade of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)- induced neuronal cell death. The neuroprotective effects of competitive and non-competitive NMDA (N-methyl-D-aspartate) antagonists against MPTP toxicity support the hypothesis that NMDA receptor-mediated events ...

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