The competitive NMDA antagonist CPP protects substantia nigra neurons from MPTP-induced degeneration in primates

URN to cite this document:: urn:nbn:de:bvb:355-epub-254216
DOI to cite this document:: 10.5283/epub.25421

Lange, Klaus W. ; Löschmann, P. A. ; Sofic, E. ; Burg, M. ; Horowski, R. ; Kalveram, K. T. ; Wachtel, H. ; Riederer, Peter

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Date of publication of this fulltext: 20 Jul 2012 11:42

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Abstract

Degeneration of nigrostriatal dopaminergic neurons is the primary histopathological feature of Parkinson's disease. The neurotoxin MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) induces a neurological syndrome in man and non-human primates very similar to idiopathic Parkinson's disease by selectively destroying dopaminergic nigrostriatal neurons. This gives rise to the hypothesis that ...