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The competitive NMDA antagonist CPP protects substantia nigra neurons from MPTP-induced degeneration in primates

Lange, Klaus W., Löschmann, P. A., Sofic, E., Burg, M., Horowski, R., Kalveram, K. T., Wachtel, H. and Riederer, Peter (1993) The competitive NMDA antagonist CPP protects substantia nigra neurons from MPTP-induced degeneration in primates. Naunyn-Schmiedeberg's archives of pharmacology 348 (6), pp. 586-592.

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Date of publication of this fulltext: 20 Jul 2012 11:42

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Abstract

Degeneration of nigrostriatal dopaminergic neurons is the primary histopathological feature of Parkinson's disease. The neurotoxin MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) induces a neurological syndrome in man and non-human primates very similar to idiopathic Parkinson's disease by selectively destroying dopaminergic nigrostriatal neurons. This gives rise to the hypothesis that ...

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Item type:Article
Date:1993
Institutions:Psychology and Pedagogy > Institut für Psychologie > Lehrstuhl für Psychologie III (Biologische, Klinische und Rehabilitationspsychologie) - Prof. Dr. Klaus W. Lange
Identification Number:
ValueType
7907775PubMed ID
Classification:
NotationType
AnimalsMESH
Behavior, Animal/drug effectsMESH
Biogenic Monoamines/metabolismMESH
CallithrixMESH
FemaleMESH
ImmunohistochemistryMESH
MPTP PoisoningMESH
MaleMESH
N-Methylaspartate/antagonists & inhibitorsMESH
Nerve Degeneration/drug effectsMESH
Neurons/enzymologyMESH
Piperazines/pharmacologyMESH
Putamen/metabolismMESH
Receptors, N-Methyl-D-Aspartate/antagonists & inhibitorsMESH
Substantia Nigra/enzymologyMESH
Tyrosine 3-Monooxygenase/metabolismMESH
Keywords:Excitatory amino acids - CPP - 3-((±)-2carboxypiperazin-4-yl)-propyl-1-phosphonic acid - NMDA receptor antagonist - Dopamine - MPTP - 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - Common marmosets - Substantia nigra degeneration - Parkinsonism
Dewey Decimal Classification:100 Philosophy & psychology > 150 Psychology
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:25421
Owner only: item control page

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