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Altered muscarinic and nicotinic receptor densities in cortical and subcortical brain regions in Parkinson's disease

URN to cite this document:
urn:nbn:de:bvb:355-epub-254233
Lange, Klaus W. ; Wells, F. R. ; Jenner, P. ; Marsden, C. D.
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Date of publication of this fulltext: 20 Jul 2012 11:31


Abstract

Muscarinic and nicotinic cholinergic receptors and choline acetyltransferase activity were studied in postmortem brain tissue from patients with histopathologically confirmed Parkinson's disease and matched control subjects. Using washed membrane homogenates from the frontal cortex, hippocampus, caudate nucleus, and putamen, saturation analysis of specific receptor binding was performed for the ...

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