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Recent advances in pharmacological therapy of Parkinson's disease

Riederer, Peter ; Lange, Klaus W. ; Youdim, M. B.



Abstract

The discovery of a selective striatal dopamine deficiency in Parkinson's disease has led to dopamine replacement therapies including L-DOPA, dopamine full and partial agonists, and MAO-B inhibitors. The development of new compounds and alternative methods of drug delivery may be able to overcome the long-term side effects of the established therapies. Overactivity of central glutamatergic systems ...

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