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Terguride stimulates locomotor activity at 2 months but not 10 months after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine treatment of common marmosets

URN to cite this document:
urn:nbn:de:bvb:355-epub-254301
Lange, Klaus W. ; Löschmann, P. A, ; Wachtel, H. ; Horowski, R. ; Jähnig, P. ; Jenner, P. ; Marsden, C. D.
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Date of publication of this fulltext: 20 Jul 2012 11:20


Abstract

The mixed dopamine (DA) agonist/antagonist terguride acts as a DA antagonist on normosensitive receptors but shows DA agonistic properties at supersensitive DA receptors. Such a compound could offer an alternative to the treatment of Parkinson's disease with indirect or direct DA agonists. The present study compares the actions of terguride, 4-12 mg/kg i.p., in naive common marmosets with its ...

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