Brain muscarinic cholinergic receptors in Huntington's disease

URN to cite this document:: urn:nbn:de:bvb:355-epub-254323

Lange, Klaus W. ; Javoy-Agid, F. ; Agid, Y. ; Jenner, P. ; Marsden, C. D.

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Date of publication of this fulltext: 20 Jul 2012 11:15

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Abstract

Muscarinic cholinergic receptors and choline acetyltransferase (ChAT) activity were studied in postmortem brain tissue from patients with Huntington's disease and matched control subjects. In comparison with controls, reductions in ChAT activity were found in the hippocampus, but not in the temporal cortex in Huntington's disease. Patients with Huntington's disease showed reduced densities of the ...