Glutamate receptor antagonism: neurotoxicity, anti-akinetic effects, and psychosis

URN to cite this document:: urn:nbn:de:bvb:355-epub-254400
DOI to cite this document:: 10.5283/epub.25440

Riederer, Peter ; Lange, Klaus W. ; Kornhuber, J. ; Jellinger, K.

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Date of publication of this fulltext: 20 Jul 2012 11:45

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Abstract

There is evidence to suggest that glutamate and other excitatory amino acids play an important role in the regulation of neuronal excitation. Glutamate receptor stimulation leads to a non-physiological increase of intracellular free Ca2+. Disturbed Ca2+ homeostasis and subsequent radical formation may be decisive factors in the pathogenesis of neurodegenerative diseases. Decreased glutamatergic ...