Behavioural effects and supersensitivity in the rat following intranigral MPTP and MPP+ administration

URN to cite this document:: urn:nbn:de:bvb:355-epub-254446
DOI to cite this document:: 10.5283/epub.25444

Lange, Klaus W.

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Date of publication of this fulltext: 20 Jul 2012 11:19

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Abstract

Unilateral intranigral injections of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) and MPP+ (1-methyl-4-phenylpyridine) were given to young rats and unilateral intranigral injections of MPTP were given to old rats. MPTP in old rats and MPP+ in young rats induced ipsiversive circling for at least one week after injection and contraversive circling after the systemic administration of ...