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Behavioural effects and supersensitivity in the rat following intranigral MPTP and MPP+ administration

Lange, Klaus W. (1990) Behavioural effects and supersensitivity in the rat following intranigral MPTP and MPP+ administration. European journal of pharmacology 175 (1), pp. 57-61.

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Abstract

Unilateral intranigral injections of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) and MPP+ (1-methyl-4-phenylpyridine) were given to young rats and unilateral intranigral injections of MPTP were given to old rats. MPTP in old rats and MPP+ in young rats induced ipsiversive circling for at least one week after injection and contraversive circling after the systemic administration of ...

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Item type:Article
Date:1990
Institutions:Psychology and Pedagogy > Institut für Psychologie > Lehrstuhl für Psychologie III (Biologische, Klinische und Rehabilitationspsychologie) - Prof. Dr. Klaus W. Lange
Identification Number:
ValueType
2323346PubMed ID
Classification:
NotationType
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/pharmacologyMESH
Aging/physiologyMESH
AnimalsMESH
Behavior, Animal/drug effectsMESH
InjectionsMESH
MPTP PoisoningMESH
MaleMESH
Nervous System Diseases/chemically inducedMESH
Pyridinium Compounds/pharmacologyMESH
RatsMESH
Rats, Inbred StrainsMESH
Receptors, Dopamine/drug effectsMESH
Spiperone/diagnostic useMESH
Stereotyped Behavior/drug effectsMESH
Substantia NigraMESH
Dewey Decimal Classification:100 Philosophy & psychology > 150 Psychology
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:25444
Owner only: item control page

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