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Bedeutung des Neurotoxins MPTP für Ätiologie und Therapie der idiopathischen Parkinsonkrankheit [Significance of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine for the etiology and therapy of idiopathic Parkinson disease]

URN to cite this document:
urn:nbn:de:bvb:355-epub-254473
DOI to cite this document:
10.5283/epub.25447
Lange, Klaus W.
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Date of publication of this fulltext: 20 Jul 2012 09:42


Abstract

Exposure of drug addicts to MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) has caused a Parkinsonian syndrome accompanied by a selective destruction of dopamine containing neurones in the pars compacta of the substantia nigra. MPTP in the human causes a severe irreversible state that very closely resembles idiopathic Parkinson's disease both in its clinical features and response to ...

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