Bedeutung des Neurotoxins MPTP für Ätiologie und Therapie der idiopathischen Parkinsonkrankheit [Significance of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine for the etiology and therapy of idiopathic Parkinson disease]

URN to cite this document:

urn:nbn:de:bvb:355-epub-254473 Copy

DOI to cite this document:

10.5283/epub.25447 Copy

Lange, Klaus W.

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Date of publication of this fulltext: 20 Jul 2012 09:42

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Details

Item type:	Article
Journal or Publication Title:	Fortschritte der Neurologie-Psychiatrie
Publisher:	Thieme
Volume:	57
Number of Issue or Book Chapter:	4
Page Range:	pp. 142-148
Date:	1989
Institutions:	Human Sciences > Institut für Psychologie > Lehrstuhl für Psychologie III (Biologische, Klinische und Rehabilitationspsychologie) - Prof. Dr. Klaus W. Lange
Identification Number:	Value Type 2656447 PubMed ID 10.1055/s-2007-1000755 DOI
Classification:	Notation Type 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine MESH Animals MESH Antiparkinson Agents/therapeutic use MESH Disease Models, Animal MESH Humans MESH Locus Coeruleus/drug effects MESH Parkinson Disease, Secondary/drug therapy MESH Pyridines/adverse effects MESH Receptors, Dopamine/drug effects MESH Substantia Nigra/drug effects MESH
Dewey Decimal Classification:	100 Philosophy & psychology > 150 Psychology
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Unknown
Item ID:	25447

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Abstract

Exposure of drug addicts to MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) has caused a Parkinsonian syndrome accompanied by a selective destruction of dopamine containing neurones in the pars compacta of the substantia nigra. MPTP in the human causes a severe irreversible state that very closely resembles idiopathic Parkinson's disease both in its clinical features and response to ...

Abstract

Exposure of drug addicts to MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) has caused a Parkinsonian syndrome accompanied by a selective destruction of dopamine containing neurones in the pars compacta of the substantia nigra. MPTP in the human causes a severe irreversible state that very closely resembles idiopathic Parkinson's disease both in its clinical features and response to pharmacological treatment. Interest in potential environmental agents that might play a role in the aetiology of idiopathic Parkinson's disease is likely to increase as the result of the discovery of the relatively simple molecule MPTP which is highly toxic to the substantia nigra. Until the discovery of the neurotoxicity of MPTP there was no effective animal model of Parkinson's disease. Administration of PTP to monkeys induces persistent parkinsonism which responds to classical antiparkinsonian therapy. The morphological and biochemical changes in the brains of the animals are more limited and selective than those seen in idiopathic Parkinson's disease. The model of MPTP-treated monkeys appears to provide a useful testbed for the evaluation of future treatments for the disease. The precise mechanism of MPTP toxicity has yet to be determined and may provide the clue to the mechanism of neuronal death in Parkinson's disease. After entering the brain MPTP is oxidized to MPP+ (1-methyl-4-phenylpyridine) at an extraneuronal site.(ABSTRACT TRUNCATED AT 250 WORDS)

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