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Modification by apomorphine of the circling behaviour in the rat due to unilateral intranigral injection of 1-methyl-4-phenylpyridine (MPP+)

Lange, Klaus W.



Abstract

Unilateral injection of MPP+ (4 micrograms/1 microliter) into the pars compacta of the substantia nigra in rats induced ipsiversive circling immediately after the injection. Ipsiversive circling was still present 7 days after the injection. Systemic injection of the dopamine agonist apomorphine induced contraversive circling. These results show that MPP+ exerts a powerful neurotoxic action on the ...

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